House’s (Hugh Laurie) patience and expertise are tested to the limit when he has to diagnose the mystery illness affecting a scientist on a remote research base at the South Pole.

His only communication with Dr Cate Milton (Sorvino) is via webcam, so House has to instruct her precisely how to run a basic set of tests on herself using the equipment she has available.

Can House pinpoint what has triggered her decline before her life starts to ebb away?