Mancini is keen to test a fresh crop of youngsters who will be expected to step up in time for Euro 2020.
Brescia wonderkid Sandro Tonali is one of the finest talents set to make his debut for the Azzurri, while Gianluca Mancini and Juventus forward Moise Kean could also receive game time.
Stefano Sensi and Leonardo Pavoletti may not start the game, but should enjoy minutes on the field at some stage.
Inter Milan star Matteo Politano is enjoying a strong loan spell at the San Siro after joining from Roma in the summer.
Italy team news: Who could start for the Azzurri? (Image: Getty Images/buildlineup.com)
Italy team news: Express Sport's predicted XI vs USA (Image: buildlineup.com)
He made his international debut in May this year and is expected to be given another chance to shine against the USA.
Mattia De Sciglio, Leonardo Bonucci and Marco Varratti look set to be the experienced heads in the youthful line-up.
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