Jose Mourinho has an injury crisis on his hands, with Eric Bailly, Chris Smalling, Luke Shaw and Marouane Fellaini all set to miss out.
Zlatan Ibrahimovic is unavailable as he is serving a one-match suspension.
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Marcus Rashford could go back to playing up front for Manchester United
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Wayne Rooney could be picked for Jose Mourinho
And according to the Daily Mirror, Rashford could spearhead the attack.
Mourinho has Anthony Martial and Wayne Rooney at his disposal, but Rashford is thought to be his preferred choice.
Rooney was forced to pull out of England’s friendly against Spain following a knee injury.
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Jose Mourinho is facing a selection dilemma
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Rather he is annoyed with the FA, and he has had previous with English football’s governing body - he was fined £50,000 after being found guilty of touchline misconduct against Burnley last month.
United will be hoping to build on their 3-1 win over Swansea before the international break.
Mourinho will fancy his chances, with Arsene Wenger having never registered a victory against him in the Premier League.