Atletico Madrid are looking to overturn a 3-0 deficit when they welcome rivals Real to the Vicente Caldeon with both teams vying for a place in the Champions League final.
In the Premier League, Arsenal are hoping for another three points against Southampton to edge closer to finishing in the top four.
ATLETICO MADRID v REAL MADRID
Atletico Madrid XI: Oblak, Gimenez, Savic, Godin, Filipe Luis, Koke, Gabi, Saul, Carrasco, Torres, Griezmann.
Real Madrid XI: Navas, Danilo, Sergio Ramos, Varane, Marcelo, Kroos, Casemiro, Modric, Isco, Benzema, Ronaldo.
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