It was just moments after Keita left the pitch that Barcelona took the lead.
Jordi Alba played a perfectly crafted ball into the box which was converted by former Liverpool forward Luis Suarez.
The Catalan club looked like they could add a second soon after but Liverpool managed to hold firm.
Reds fans felt the loss of Keita had a big impact on the game at the Nou Camp.
Liverpool star Naby Keita was forced off early against Barcelona (Image: GETTY)
Liverpool boss Jurgen Klopp comforted Naby Keita as he left the field (Image: GETTY)
One tweeted: "Keita was so important in the midfield #BarcaLiverpool."
Another said: "Keita loss has been a massive loss for Liverpool, the game seems to have tipped into Barcelona’s favour.#FCBLIV."
"Since Keita came off we’ve been struggling," a third explained.
Pundit Robbie Savage that the introduction of Henderson for Keita seemed to allow Jordi Alba more space for Barcelona.
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Luis Suarez netted the opener for Barcelona against Liverpool (Image: GETTY)