Arsenal will have to cope without Lukas Podolski for two months
The Germany forward sustained the injury after pulling up during Tuesday's Champions League play-off victory over Fenerbahce.
The injury is worse than first feared, with Arsenal boss Arsene Wenger originally under the impression Podolski would be out for three weeks.
Speaking to the club's official website, arsenal.com, Wenger said: "It is bad news about Lukas Podolski as he will be out for eight to 10 weeks.
Lukas Podolski injured his left hamstring during the win on Tuesday
Lukas Podolski was Arsenal's two-goal hero at the weekend
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"His hamstring is much more damaged than we thought at the start.
"It is very disappointing and we have paid a very heavy price for that win [over Fenerbahce]. We have to be patient now."
Arsene Wenger only expected Podolski to be out for three weeks
Jack Wilshere should be fit for the north London derby
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Podolski will now be forced to sit out of Germany's World Cup qualifiers in September and October.
However, there is some positive fears with Aaron Ramsey and Jack Wilshere, who was on the receiving end of some meaty challenges against Fenerbahce, will be fit for the north London derby on Sunday.