Both men could be given the night off at Hush Park, with fringe players Sergio Romero, Victor Lindelof, Scott McTominay and Angel Gomes all in with a chance of featuring.
Marcus Rashford is expected to lead the line while Luke Shaw and Marcos Rojo could also make the starting XI.
Take a look through the gallery above to see how Manchester United could line up when they take on Yeovil Town in the FA Cup fourth round.
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